Malagelada J R, Rees W D, Mazzotta L J, Go V L
Gastroenterology. 1980 Feb;78(2):286-93.
Gastroparesis is a relatively uncommon but clinically troublesome disorder that develops in some patients with diabetes mellitus or after gastric operations. Its pathogenesis remains obscure. We used a manometric technique to record pressure changes in fasting patients in the gastric fundus, distal stomach, and adjacent small bowel of patients with severe gastroparesis, asymptomatic diabetic patients, asymptomatic postsurgical patients, and healthy controls. Patients with gastroparesis had normal interdigestive motor cycles (phase III) in the intestine but not in the stomach. Sporadic motor activity in the stomach (phase II) also was markedly reduced. Metoclopramide and bethanecol significantly increased gastric motor activity in these patients, often triggering an intense burst of motor activity in the stomach, similar to phase III. These observations suggest that gastroparesis is a potentially reversible disorder and should encourage further attmpts for pharmacologic control of the syndrome.
胃轻瘫是一种相对不常见但临床上令人困扰的疾病，在一些糖尿病患者或胃部手术后的患者中出现。其发病机制仍不清楚。我们使用测压技术记录了重度胃轻瘫患者、无症状糖尿病患者、无症状术后患者和健康对照者在空腹时胃底、胃远端和相邻小肠的压力变化。胃轻瘫患者肠道的消化间期运动周期（Ⅲ期）正常，但胃部不正常。胃部的散在运动活动（Ⅱ期）也明显减少。甲氧氯普胺和氨甲酰甲胆碱显著增加了这些患者的胃运动活动，常常引发胃部强烈的运动活动爆发，类似于Ⅲ期。这些观察结果表明胃轻瘫是一种潜在可逆的疾病，应该鼓励进一步尝试对该综合征进行药物控制。
