Perkel M S, Hersh T, Moore C, Davidson E D
Am J Gastroenterol. 1980 Sep;74(3):231-6.
Fifty-five patients with delayed gastric emptying and the symptoms of nausea, vomiting, postprandial bloating and early satiety were treated with metoclopramide. Obstruction was excluded by upper endoscopy and standard upper gastrointestinal series. None were on medication known to retard gastric emptying. All patients had an abnormal barium burger radiologic study. Twenty-one patients had had previous vagotomy and drainage procedure, five had diabetic gastroparesis and 29 had idiopathic delayed gastric emptying. Metoclopramide significantly decreased the symptom scores of the surgical and idiopathic patients. When all patients were analyzed together, there was a significant improvement in both the metoclopramide and placebo treated patients. When, however, the improvement on metoclopramide was compared to the improvement on placebo, there was a significant metoclopramide effect beyond the placebo effect. Thus, metoclopramide is an effective agent in treating the symptom-complex of patients with delayed gastric emptying.
55例有胃排空延迟及恶心、呕吐、餐后腹胀和早饱症状的患者接受了甲氧氯普胺治疗。通过上消化道内镜检查和标准上消化道造影排除梗阻。所有患者均未服用已知会延缓胃排空的药物。所有患者的钡餐放射学检查均异常。21例患者曾接受过迷走神经切断术和引流手术，5例患有糖尿病性胃轻瘫，29例患有特发性胃排空延迟。甲氧氯普胺显著降低了手术患者和特发性患者的症状评分。当对所有患者进行综合分析时，甲氧氯普胺治疗组和安慰剂治疗组均有显著改善。然而，将甲氧氯普胺的改善效果与安慰剂的改善效果进行比较时，甲氧氯普胺的效果显著超过安慰剂效应。因此，甲氧氯普胺是治疗胃排空延迟患者症状复合体的有效药物。
