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[人类白细胞抗原与糖尿病]

[HL-A antigens and diabetes mellitus].

作者信息

Minev M, Khartarska S, Karalambev N, Genov Zh

出版信息

Vutr Boles. 1978;17(6):66-71.

PMID:735032
Abstract

Association of juvenile diabetes with antigen B8 and B15 was established with the comparison of the phenotype incidence of 28 HLA antigens from locus A and B among 1085 healthy control subjects and 200 patients with diabetes mellitus (74 with juvenile insulin-dependent type and 126 with insulin-independent diabetes in adults). Only the incidence of antigens B15 and Bw 21 was established to be increased in the cases of insulin-dependent type of diabetes in adults. That raises a new interest in the further study of the problem.

摘要

通过比较1085名健康对照者和200例糖尿病患者(74例青少年胰岛素依赖型和126例成人非胰岛素依赖型糖尿病)中来自A和B位点的28种HLA抗原的表型发生率,确定了青少年糖尿病与抗原B8和B15之间的关联。仅确定在成人胰岛素依赖型糖尿病病例中抗原B15和Bw21的发生率增加。这引发了对该问题进一步研究的新兴趣。

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