Comparative study of the cellular localization of three polycyclic hydrocarbons differing in their carcinogenicity.
作者信息
Stora C
出版信息
Oncology. 1980;37(1):23-6. doi: 10.1159/000225395.
PMID:7350550
Abstract
Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both in the cytoplasm and the nucleus of cells and in numerous organs. The noncarcinogenic compound dibenz(a,c)anthracene was undetectable. This work suggests that the differences in carcinogenicity may result in the possibility of the compounds to penetrate the nucleus of target cells.
摘要
相似文献
1
Comparative study of the cellular localization of three polycyclic hydrocarbons differing in their carcinogenicity.
Oncology. 1980;37(1):23-6. doi: 10.1159/000225395.
2
DNA binding and its relationship to carcinogenesis by different polycyclic hydrocarbons.DNA结合及其与不同多环芳烃致癌作用的关系。
Int J Cancer. 1977 Jan;19(1):122-7. doi: 10.1002/ijc.2910190117.
3
4
Effects of metabolism on the binding of polycyclic hydrocarbons to nuclear subfractions of cultured AKR mouse embryo cells.
Cancer Res. 1977 May;37(5):1490-6.
5
6
Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols.苯并(a)芘和二苯并(a,h)蒽与小鼠和大鼠肝细胞溶质中芳烃受体的结合。
Cancer Res. 1984 Apr;44(4):1426-32.
7
Metabolite repression inhibits degradation of benzo[a]pyrene and dibenz[a,h]anthracene by Stenotrophomonas maltophilia VUN 10,003.代谢物阻遏抑制嗜麦芽窄食单胞菌VUN 10,003对苯并[a]芘和二苯并[a,h]蒽的降解。
J Ind Microbiol Biotechnol. 2002 Feb;28(2):88-96. doi: 10.1038/sj/jim/7000216.
9
10
Comparative penetration of polycyclic hydrocarbons through the rat placenta into the fetus.多环烃经大鼠胎盘向胎儿的穿透比较
Bull Exp Biol Med. 1974 Aug;77(2):169-71. doi: 10.1007/BF00809625.
Zotero 插件