Pizzo P A, Ladisch S, Ribichaud K
Cancer. 1980 Jan 1;45(1):206-7. doi: 10.1002/1097-0142(19800101)45:1<206::aid-cncr2820450133>3.0.co;2-p.
Seventy-eight pediatric cancer patients were treated for gram-positive bacterial septicemia during a 10-year period (1968-1977). Sixty-one (78%) of the patients were granulocytopenic (PMNs less than 500/mm3) at the onset of the septic episode. All the patients whose granulocytopenia resolved (PMNs greater than 500/mm3) within one week of therapy recovered without sequelae. However, 7 of 15 patients (47%) who remained granulocytopenic for more than 7 days and who were treated with a single antibiotic developed a second sepsis with a gram-negative organism. In contrast, second infections were not observed in 24 patients with PMNs less than 500/mm3 for more than 7 days who were treated with broad spectrum antibiotics (p less than 0.002), suggesting that a broad-spectrum antibiotic regimen may be preferable when a cancer patient has prolonged granulocytopenia.
在10年期间（1968 - 1977年），78名儿童癌症患者接受了革兰氏阳性菌败血症的治疗。61名（78%）患者在败血症发作时粒细胞减少（中性粒细胞小于500/mm³）。所有在治疗一周内粒细胞减少症得到缓解（中性粒细胞大于500/mm³）的患者均康复且无后遗症。然而，15名粒细胞减少持续超过7天且接受单一抗生素治疗的患者中有7名（47%）发生了由革兰氏阴性菌引起的第二次败血症。相比之下，24名中性粒细胞小于500/mm³超过7天且接受广谱抗生素治疗的患者未观察到二次感染（p小于0.002），这表明当癌症患者存在长期粒细胞减少时，广谱抗生素治疗方案可能更可取。
