Friedenberg W R, Marx J J
Cancer. 1980 Jan 1;45(1):91-7. doi: 10.1002/1097-0142(19800101)45:1<91::aid-cncr2820450116>3.0.co;2-#.
Lithium affects an increase in granulocyte counts in humans and has been promoted in the treatment of granulocytopenia and as adjuvant cancer chemotherapy to reduce the incidence of bacterial infections. In this study, eight healthy volunteers were studied by means of a panel of quantitative and cellular function tests before and after a seven-day course of lithium carbonate. Granulocyte, lymphocyte, and platelet function was assessed by the test panel. This panel included T cell and B cell enumeration, lymphocyte transformation to a number of mitogens and antigens, phagocytic and bactericidal activities of peripheral leukocytes, nitroblue tetrazolium (NBT) reduction, chemotaxis, chemiliminescence, platelet aggregation studies, and Ivy bleeding time. The was a significant reduction in bactericidal capacity (p less than 0.005) and a significant reduction in lymphocyte response to PPD (p less than 0.01). Although lithium increase the granulocyte count, the reduction in bactericidal capacity of granulocytes may reduce the beneficial effect of the granulocytosis. Prospective clinical studies are indicated to assess the clinical efficacy of the drug.
锂可使人体粒细胞计数增加，已被用于治疗粒细胞减少症，并作为辅助癌症化疗药物以降低细菌感染的发生率。在本研究中，对8名健康志愿者在服用碳酸锂7天疗程前后进行了一系列定量和细胞功能测试。通过测试组评估粒细胞、淋巴细胞和血小板功能。该测试组包括T细胞和B细胞计数、淋巴细胞对多种有丝分裂原和抗原的转化、外周血白细胞的吞噬和杀菌活性、硝基蓝四氮唑（NBT）还原、趋化性、化学发光、血小板聚集研究以及艾维出血时间。杀菌能力显著降低（p<0.005），淋巴细胞对结核菌素纯蛋白衍生物（PPD）的反应显著降低（p<0.01）。虽然锂可增加粒细胞计数，但粒细胞杀菌能力的降低可能会削弱粒细胞增多的有益作用。需要进行前瞻性临床研究以评估该药物的临床疗效。
