Bond J H, Currier B E, Buchwald H, Levitt M D
Gastroenterology. 1980 Mar;78(3):444-7.
[14C]Sucrose absorption was studied in 4 healthy controls and 4 patients after jejunoileal bypass using an ileal perfusion technique which made it possible to distinguish 14C-absorption in the small bowel from that occurring in the colon. Healthy controls failed to absorb 2--4% of a 50-g dose of [14C]sucrose in the small bowel; however, virtually none of the [14C] appeared in feces in a dialyzable form with appreciable osmotic activity. In bypass patients, the small bowel failed to absorb 29--84% of the 50-g dose of [14C]sucrose. Approximately two-thirds of the nonabsorbed [14C] was in the form of sucrose and the remainder was nearly all present as monosaccharides. A mean of only 42% of the [14C] Not absorbed in the small bowel appeared in the feces and only about one-third of this fecal [14C] was in a dialyzable form with appreciable osmotic activity. Thus, the colon plays an important role in carbohydrate malabsorption by salvaging carbohydrate and reducing osmotic activity of the nonabsorbed sugar. This conlonic function appears to depend upon bacterial metabolism of the carbohydrate, and individual variations in diarrhea and weight loss associated with carbohydrate malabsorption could reflect individual differences in the bacterial flora of the colon.
采用回肠灌注技术研究了4名健康对照者和4名空肠回肠旁路术后患者对[14C]蔗糖的吸收情况，该技术能够区分小肠中[14C]蔗糖的吸收与结肠中发生的吸收。健康对照者在小肠中未能吸收50克[14C]蔗糖剂量的2% - 4%；然而，实际上没有任何[14C]以具有明显渗透活性的可透析形式出现在粪便中。在旁路手术患者中，小肠未能吸收50克[14C]蔗糖剂量的29% - 84%。未吸收的[14C]中约三分之二为蔗糖形式，其余几乎全部以单糖形式存在。小肠中未吸收的[14C]平均仅有42%出现在粪便中，且粪便中[14C]仅有约三分之一是具有明显渗透活性的可透析形式。因此，结肠通过挽救碳水化合物并降低未吸收糖的渗透活性，在碳水化合物吸收不良中发挥重要作用。这种结肠功能似乎依赖于碳水化合物的细菌代谢，与碳水化合物吸收不良相关的腹泻和体重减轻的个体差异可能反映了结肠细菌菌群的个体差异。
