膳食钙、镁和磷对大鼠磷酸盐尿路结石的影响。

Effect of dietary calcium, magnesium, and phosphorus on phosphate urolithiasis in rats.

作者信息

Chow F H, Taton G F, Boulay J P, Lewis L D, Remmenga E E, Hamar D W

出版信息

Invest Urol. 1980 Jan;17(4):273-6.

Abstract

Female Wistar rats were fed a basal diet containing various concentrations of calcium, phosphorus, and magnesium: calcium and phosphorus at 0.4, 0.5, 0.8, 1.0, 1.5, and 2 per cent and magnesium at 0.2, 0.4, 0.8, and 1 per cent of the diet dry matter. Two types of uroliths developed: magnesium phosphate in the renal pelves, bladders, and/or ureters of rats fed rations containing 1 per cent magnesium with either 1.0 or 0.5 per cent phosphorus and calcium phosphate uroliths in the renal tubules at the corticomedullary junction of rats fed rations containing phosphorus equal to or greater than 0.8 per cent and magnesium equal to or less than 0.8 per cent. The incidence and severity of calcium phosphate uroliths were reduced by increasing the magnesium concentration in the diet from 0.2 to 0.8 per cent and by increasing the calcium-to-phosphorus ratio to greater than 1. Results of this study indicated that the interactions among dietary calcium, magnesium, and phosphorus seemed to affect the incidence, severity, and type of uroliths in rats.

摘要

给雌性Wistar大鼠喂食含有不同浓度钙、磷和镁的基础日粮：钙和磷的含量分别为日粮干物质的0.4%、0.5%、0.8%、1.0%、1.5%和2%，镁的含量分别为日粮干物质的0.2%、0.4%、0.8%和1%。形成了两种类型的尿路结石：在喂食含1%镁且含1.0%或0.5%磷日粮的大鼠的肾盂、膀胱和/或输尿管中形成磷酸镁结石，在喂食含磷量等于或大于0.8%且含镁量等于或小于0.8%日粮的大鼠的皮质髓质交界处的肾小管中形成磷酸钙结石。通过将日粮中的镁浓度从0.2%提高到0.8%以及将钙磷比提高到大于1，可降低磷酸钙结石的发生率和严重程度。本研究结果表明，日粮中的钙、镁和磷之间的相互作用似乎会影响大鼠尿路结石的发生率、严重程度和类型。