中性粒细胞源性嗜酸性粒细胞趋化因子（ECF）对人和豚鼠皮肤的作用。

Effect of neutrophil-derived eosinophil chemotactic factor (ECF) in human and guinea pig skin.

作者信息

Czarnetzki B M, Frosch P J, Vakilzadeh F, Panneck W B

出版信息

J Invest Dermatol. 1980 Feb;74(2):109-11. doi: 10.1111/1523-1747.ep12520024.

DOI:10.1111/1523-1747.ep12520024

Abstract

The in vivo effectiveness of eosinophil chemotactic factor (ECF), secreted in vitro by human neutrophils (PMN) during phagocytosis, is tested in 2 model systems. Injection of ECF into guinea pig ears causes a preferential attraction of eosinophils with time that is more marked in animals with preexisting eosinophilia. In the same model system, activated serum attracts fewer eosinophils and more PMN. In human skin windows, ECF and activated serum are equally effective on a quantitative basis, but ECF is more selective for eosinophils in patients with eosinophilia. With normal controls, ECF and activated serum attract PMN equally well. The studies confirm previous in vitro observations on the properties of ECF and suggest a potentially significant role of this factor during pathological processes.

摘要

对人中性粒细胞（PMN）在吞噬过程中体外分泌的嗜酸性粒细胞趋化因子（ECF）的体内有效性，在2个模型系统中进行了测试。将ECF注射到豚鼠耳部，随着时间推移会导致嗜酸性粒细胞的优先吸引，这在已有嗜酸性粒细胞增多的动物中更为明显。在同一模型系统中，活化血清吸引的嗜酸性粒细胞较少，而吸引的PMN较多。在人体皮肤窗实验中，从定量角度看，ECF和活化血清同样有效，但ECF对嗜酸性粒细胞增多患者的嗜酸性粒细胞更具选择性。对于正常对照，ECF和活化血清对PMN的吸引效果相同。这些研究证实了先前关于ECF特性的体外观察结果，并表明该因子在病理过程中可能具有重要作用。