Donovan E F, Tsang R C, Steichen J J, Strub R J, Chen I W, Chen M
J Pediatr. 1980 Feb;96(2):305-10. doi: 10.1016/s0022-3476(80)80835-3.
Twenty pre-eclamptic mothers treated with MgSO4 and their newborn infants were studied prospectively to determine the clinical and biochemical effects of hypermagnesemia. Maternal serum magnesium concentration rose to 4.4 mg/dl at delivery and was accompanied by a fall in maternal serum calcium concentration during labor. Neonatal serum Mg concentration remained elevated for the first 72 hours of life (mean at 72 hours = 3.0 mg/dl). Serum Mg concentration was higher in premature infants and in babies with birth asphyxia and/or hypotonia. Serum Ca concentration was higher and serum PTH was lower in hypermagnesemic study infants when compared to a retrospectively selected, matched froup of control infants. We speculate that elevated serum Mg values in these infants result in a shift of Ca from bone to plasma, and that elevated Mg and Ca concentrations further suppress neonatal parathyroid function.
对20名接受硫酸镁治疗的先兆子痫母亲及其新生儿进行了前瞻性研究，以确定高镁血症的临床和生化影响。分娩时母亲血清镁浓度升至4.4mg/dl，分娩过程中母亲血清钙浓度下降。新生儿血清镁浓度在出生后72小时内一直升高（72小时时平均值为3.0mg/dl）。早产儿以及有出生窒息和/或肌张力低下的婴儿血清镁浓度更高。与一组回顾性选择的匹配对照婴儿相比，高镁血症研究婴儿的血清钙浓度更高，血清甲状旁腺激素更低。我们推测，这些婴儿血清镁值升高导致钙从骨骼转移到血浆，而升高的镁和钙浓度进一步抑制新生儿甲状旁腺功能。
