Rasch D K, Huber P A, Richardson C J, L'Hommedieu C S, Nelson T E, Reddi R
J Pediatr. 1982 Feb;100(2):272-6. doi: 10.1016/s0022-3476(82)80654-9.
To investigate the effects on the newborn infant of maternal magnesium therapy for treatment of pre-eclampsia, we studied 36 hypermagnesemic infants born to pre-eclamptic mothers treated with MgSO4, 18 neonates born to untreated pre-eclamptic mothers, and 25 infants born to normal mothers. Impairment of neuromuscular transmission, as well as neurobehavioral differences when compared to controls, were found in hypermagnesemic infants. Awareness of the changes produced in the neonate by magnesium is important for accurate clinical assessment of the infant's condition, as well as for anticipating the postnatal interaction of magnesium with other drugs administered during labor and delivery.
为了研究母亲使用镁剂治疗先兆子痫对新生儿的影响，我们对36名硫酸镁治疗的先兆子痫母亲所生的高镁血症婴儿、18名未经治疗的先兆子痫母亲所生的新生儿以及25名正常母亲所生的婴儿进行了研究。高镁血症婴儿出现了神经肌肉传递受损以及与对照组相比的神经行为差异。了解镁对新生儿产生的变化对于准确临床评估婴儿状况以及预测分娩期间镁与其他药物的产后相互作用非常重要。
