头孢唑林用于肾功能不全儿童。

Cefazolin in children with renal insufficiency.

作者信息

Hiner L B, Baluarte H J, Polinsky M S, Gruskin A B

出版信息

J Pediatr. 1980 Feb;96(2):335-9. doi: 10.1016/s0022-3476(80)80842-0.

Abstract

Cefazolin (7 mg/kg) were administered to 11 children with renal insufficiency and to ten children on hemodialysis. The serum half-life of the drug was progressively prolonged as glomerular filtration rate fell. The serum half-life of cefazolin was variably prolonged in those children on hemodialysis, but their serum levels of cefaxolin had dropped by 35 to 65% during dialysis. Most had no measurable level prior to the next dialysis. Dosage recommendations are made for both groups of patients.

摘要

给11名肾功能不全儿童和10名接受血液透析的儿童使用头孢唑林（7毫克/千克）。随着肾小球滤过率下降，该药物的血清半衰期逐渐延长。接受血液透析的儿童中，头孢唑林的血清半衰期延长情况各异，但在透析期间他们的头孢唑啉血清水平下降了35%至65%。大多数儿童在下一次透析前血清水平无法测出。针对两组患者给出了剂量建议。