McLain D A, Garriga F J, Kantor O S
JAMA. 1980;243(8):763-4.
Three hypertensive patients receiving ticrynafen, a new uricosuric diuretic, experienced adverse reactions. One patient experienced acute renal failure, the second experienced a renal stone, and the third had a fatal hemorrhage while receiving anticoagulation therapy with warfarin sodium. All complications can be explained by known actions of the drug and are preventable. However, these reactions illustrate the potential hazards from widespread substitution of ticrynafen for thiazide diuretics in the treatment of hypertension.
三名正在服用新型促尿酸尿性利尿剂替尼酸的高血压患者出现了不良反应。一名患者出现急性肾衰竭，第二名患者出现肾结石，第三名患者在接受华法林钠抗凝治疗时发生致命性出血。所有并发症都可以用该药物已知的作用来解释，并且是可以预防的。然而，这些反应说明了在高血压治疗中广泛用替尼酸替代噻嗪类利尿剂的潜在危害。
