赤藓红（红色3号）及其非特异性生化作用：与行为变化有何关系？

Erythrosine (Red No. 3) and its nonspecific biochemical actions: what relation to behavioral changes?

作者信息

Mailman R B, Ferris R M, Tang F L, Vogel R A, Kilts C D, Lipton M A, Smith D A, Mueller R A, Breese G R

出版信息

Science. 1980 Feb 1;207(4430):535-7. doi: 10.1126/science.7352264.

Abstract

Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control of 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.

摘要

生化研究表明，赤藓红抑制多巴胺摄取到脑突触体制剂中的能力取决于测定混合物中组织的浓度。因此，赤藓红抑制多巴胺摄取这一发现（如果属实，将为费因戈尔德儿童多动症假说提供一个合理的解释）可能仅仅是与脑膜非特异性相互作用导致的假象。此外，虽然经肠胃外给予赤藓红（每千克50毫克）不会改变对照大鼠或6-羟基多巴胺处理大鼠的运动活性，但赤藓红（每千克50至300毫克）在“冲突”范式中减弱了惩罚的效果。