Barrada M I, Blomquist C H, Kotts C
Am J Obstet Gynecol. 1980 Jan 15;136(2):234-8. doi: 10.1016/0002-9378(80)90603-1.
Pregnant rabbits were injected with either 0.8 mg of betamethasone or with a comparable volume of saline on days 24 and 25 of gestation and delivered by cesarean section on day 26. There was a significant reduction in the weight of fetuses and in the weights of fetal brain, lungs, liver, and placenta in betamethasone-treated animals. With respect to the fetal brain, the concentration of DNA, the average of cell number, cell size, cell weight, and cell phospholipids were unaffected whereas the concentrations of phospholipids and protein were elevated in the treatment group.
在妊娠第24天和第25天，给怀孕的兔子注射0.8毫克倍他米松或等量的生理盐水，并于第26天进行剖宫产。在接受倍他米松治疗的动物中，胎儿体重以及胎儿脑、肺、肝和胎盘的重量显著降低。关于胎儿脑，DNA浓度、细胞数量平均值、细胞大小、细胞重量和细胞磷脂未受影响，而治疗组中磷脂和蛋白质的浓度升高。
