Czarnetzki H D, Kothe W, Hartig W, Faust H, Albert H
Z Exp Chir. 1978;11(5):328-34.
By use of stable isotope labeled amin acid 15N-glycine the effects of truncular subdiaphragmatic vagotomy and of pyloroplasty, which are comprised in the method of bionomic gastric operations, were studied separately. The assessment of nitrogen equilibrium in rats after only truncular vagotomy, only pyloroplasty, truncular vagotomy combined with pyloroplasty, and without surgery serving as controls yielded results as following: After truncular vagotomy the 15N equilibrium was worse than in the control animals or after pyloroplasty only. The cause of that is an enhanced nitrogen loss in urine. After truncular vagotomy with pyloroplasty, though, 15N excretion in feces was significantly higher than after only pyloroplasty. It may be concluded from these results that truncular vagotomy is primarily responsible for the disturbances in protein metabolism. Pyloroplasty in combination with truncular subdiaphragmatic vagotomy also causes a higher nitrogen excretion in the feces indeed.
通过使用稳定同位素标记的氨基酸15N-甘氨酸，分别研究了生物胃手术方法中包含的经腹膈下迷走神经切断术和幽门成形术的效果。对仅行迷走神经切断术、仅行幽门成形术、迷走神经切断术联合幽门成形术以及未手术作为对照的大鼠进行氮平衡评估，结果如下：迷走神经切断术后15N平衡比对照动物或仅行幽门成形术后更差。其原因是尿中氮损失增加。然而，迷走神经切断术联合幽门成形术后，粪便中15N排泄量明显高于仅行幽门成形术后。从这些结果可以得出结论，迷走神经切断术是蛋白质代谢紊乱的主要原因。幽门成形术联合经腹膈下迷走神经切断术确实也会导致粪便中氮排泄量增加。
