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Alkylation of nucleic acids by N-nitrosodi-n-propyl-amine: evidence that carbonium ions are not significantly involved.

作者信息

Park K K, Archer M C, Wishnok J S

出版信息

Chem Biol Interact. 1980 Feb;29(2):139-44. doi: 10.1016/0009-2797(80)90028-9.

DOI:10.1016/0009-2797(80)90028-9
PMID:7353229
Abstract

Administration of N-nitrosodi-n-propylamine to rats leads to the formation of 7-n-propylguanine but not 7-isopropylguanine in hepatic DNA. For RNA, a small amount of the rearranged adduct is formed. Alkylation of DNA and RNA therefore appears to occur primarily via a bimolecular reaction rather than a unimolecular pathway involving free alkyl cations.

摘要

相似文献

1
Alkylation of nucleic acids by N-nitrosodi-n-propyl-amine: evidence that carbonium ions are not significantly involved.
Chem Biol Interact. 1980 Feb;29(2):139-44. doi: 10.1016/0009-2797(80)90028-9.
2
Reactive intermediates from nitrosamines.亚硝胺产生的反应中间体。
Adv Exp Med Biol. 1981;136 Pt B:1027-35.
3
n-Propyldiazonium ion alkylates O6 of guanine with rearrangement, but alkylates N-7 without rearrangement.正丙基重氮离子使鸟嘌呤的O6烷基化并伴有重排，但使N-7烷基化时不发生重排。
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Alkylation of DNA and RNA by [14C]dimethylnitrosamine in hydroxyurea-synchronized regenerating rat liver.[14C]二甲基亚硝胺在羟基脲同步化再生大鼠肝脏中对DNA和RNA的烷基化作用。
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Alkylation of rat liver nucleic acids not related to carcinogenesis by N-nitrosamines.
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6
Formation and subsequent excision of O6-ethylguanine from DNA of rat liver following administration of diethylnitrosamine.给予二乙基亚硝胺后大鼠肝脏DNA中O6-乙基鸟嘌呤的形成及随后的切除
Cancer Res. 1979 Dec;39(12):5003-9.
7
Reactive metabolites from N-nitrosamines.N-亚硝胺的反应性代谢产物。
Adv Exp Med Biol. 1991;283:521-4. doi: 10.1007/978-1-4684-5877-0_68.
8
Alkylation of nucleic acids of rat liver and lung by deuterated N-nitrosodiethylamine in vivo.
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9
Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine.小剂量二甲基亚硝胺作用后大鼠肝脏和肾脏中脱氧核糖核酸O6-甲基鸟嘌呤的形成及随后的去除
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10
Effect of chronic administration of dimethylnitrosamine on the excision of O6-methylguanine from rat liver DNA.长期给予二甲基亚硝胺对大鼠肝脏DNA中O6-甲基鸟嘌呤切除的影响。
Cancer Lett. 1976 Nov;2(2):79-85. doi: 10.1016/s0304-3835(76)80015-8.

引用本文的文献

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2
alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-N-methylaniline.致癌亚硝胺体外代谢中的α-羟基化途径：N-亚硝基二甲胺和N-亚硝基-N-甲基苯胺
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6489-93. doi: 10.1073/pnas.78.10.6489.
3
O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.
聚（dA-dT）中胸苷上的O4-甲基、-乙基或-异丙基取代基在复制时都会导致转变。
Proc Natl Acad Sci U S A. 1986 Jan;83(1):28-32. doi: 10.1073/pnas.83.1.28.