奈替米星：其体外活性及与青霉素类化合物的协同作用。
Netilmicin: its in vitro activity and synergism with penicillin compounds.
作者信息
Thadepalli H, Roy I
出版信息
Chemotherapy. 1980;26(1):12-20. doi: 10.1159/000237878.
The in vitro efficacy of netilmicin and its synergism with penicillins were examined. Netilmicin was effective against E. coli, indole-negative and -positive Proteus, Klebsiella, Enterobacter, Salmonella, Shigella and Serratia. Netilmicin was less effective than other aminoglycosides against Citrobacter and Pseudomonas. A combination of netilmicin and piperacillin synergistically inhibited Enterococci. Netilmicin was not synergistic with either penicillin or carbenicillin against Enterococci. Netilmicin with either carbenicillin, ticarcillin or piperacillin synergistically inhibited Pseudomonas aeruginosa, but no such synergism was noted against highly resistant strains of Pseudomonas.
对奈替米星的体外药效及其与青霉素的协同作用进行了研究。奈替米星对大肠杆菌、吲哚阴性和阳性变形杆菌、克雷伯菌属、肠杆菌属、沙门菌属、志贺菌属和沙雷菌属有效。奈替米星对柠檬酸杆菌属和假单胞菌属的效力低于其他氨基糖苷类药物。奈替米星与哌拉西林联合使用可协同抑制肠球菌。奈替米星与青霉素或羧苄西林联合使用对肠球菌无协同作用。奈替米星与羧苄西林、替卡西林或哌拉西林联合使用可协同抑制铜绿假单胞菌，但对高度耐药的铜绿假单胞菌菌株未观察到这种协同作用。
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