多巴胺能前体药物：5,6-和6,7-ADTN作为二苯甲酰酯给药后的脑内浓度及神经化学效应 - Suppr

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Dopaminergic prodrugs: brain concentrations and neurochemical effects of 5,6- and 6,7-ADTN after administration as dibenzoyl esters.

作者信息

Westerink B H, Dijkstra D, Feenstra M G, Grol C J, Horn A S, Rollema H, Wirix E

出版信息

Eur J Pharmacol. 1980 Jan 11;61(1):7-15. doi: 10.1016/0014-2999(80)90376-3.

DOI:10.1016/0014-2999(80)90376-3

PMID:7353583

Abstract

摘要

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Dopaminergic prodrugs: brain concentrations and neurochemical effects of 5,6- and 6,7-ADTN after administration as dibenzoyl esters.多巴胺能前体药物：5,6-和6,7-ADTN作为二苯甲酰酯给药后的脑内浓度及神经化学效应

Eur J Pharmacol. 1980 Jan 11;61(1):7-15. doi: 10.1016/0014-2999(80)90376-3.

The significance of COMT activity in controlling dopamine agonist levels in brain and serum: studies with a prodrug and a metabolite of 6,7-ADTN.

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A prodrug of ADTN: selectivity of dopaminergic action and brain levels of ADTN.ADTN的前体药物：多巴胺能作用的选择性及ADTN的脑内水平

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Brain levels and metabolism of the dopaminergic agonist 2-amino-6,7-dihydroxytetrahydronaphthalene after administration of various prodrugs.给予各种前体药物后多巴胺能激动剂2-氨基-6,7-二羟基四氢萘的脑内水平及代谢情况

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Selective storage in vivo of 5,6-ADTN in dopamine-rich areas of the rat brain.5,6-二氨基四硝基苯在大鼠脑富含多巴胺区域的体内选择性储存。

Eur J Pharmacol. 1980 Jun 13;64(2-3):115-21. doi: 10.1016/0014-2999(80)90034-5.

A new dopaminergic prodrug.一种新型多巴胺能前体药物。

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Effects of ADTN and various other 2-aminotetralin derivatives on the efflux of 3H-dopamine from rat striatal slices.ADTN及其他多种2-氨基四氢萘衍生物对大鼠纹状体切片中3H-多巴胺流出的影响。

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[3H]2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalen (ADTN). Regional distribution and in vivo binding after acute and chronic drug treatment.[3H]2-氨基-6,7-二羟基-1,2,3,4-四氢萘（ADTN）。急性和慢性药物治疗后的区域分布及体内结合情况。

Neurochem Res. 1980 Jun;5(6):641-51. doi: 10.1007/BF00964785.

S(-)DP-5,6-ADTN as an in vivo dopamine receptor ligand: relation between displacement by dopamine agonists and their pharmacological effects.

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Involvement of both dopaminergic and alpha-adrenergic receptors in the hypomotility induced by dibenzoyl-6,7-ADTN.多巴胺能和α-肾上腺素能受体均参与二苯甲酰-6,7-ADTN诱导的运动减弱。

Eur J Pharmacol. 1981 Apr 9;70(4):541-50. doi: 10.1016/0014-2999(81)90365-4.

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Inhibition of rat brain monoamine oxidase type A by 2-aminotetralin and tetrahydroisoquinoline analogues of dopamine.2-氨基四氢萘和多巴胺的四氢异喹啉类似物对大鼠脑A型单胺氧化酶的抑制作用

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Brain and serum concentrations of dopamine analogues after peripheral administration to rats.大鼠外周给药后多巴胺类似物在脑和血清中的浓度

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