Rieu J P, Mouzin G, Cousse H, Boucherle A
J Pharm Sci. 1980 Jan;69(1):49-53. doi: 10.1002/jps.2600690114.
Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2-chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.
研究了衣康酸酐与2-氯联苯之间通过傅克反应合成伊他诺酮的过程。制备并研究了与可能的杂质相对应的五种异构体,以完善一种可靠且实用的方法来检测伊他诺酮中的这些杂质。