Heritage A S, Stumpf W E, Sar M, Grant L D
Science. 1980 Mar 21;207(4437):1377-9. doi: 10.1126/science.7355296.
Sex steroid hormones and catecholamines have physiological interactions in the brain. By the combined use of autoradiography and fluorescence histochemistry, steroid hormone target sites and catecholamine neurons were visualized simultaneously in the same tissue preparation. By this dual localization method, [3H]estradiol and [3H]dihydrotestosterone target sites were identified in nuclei of many catecholamine cell bodies in the brainstem, and catecholamine nerve terminals were observed near certain steroid hormone target neurons. These results suggest close anatomical interrelations between steroid hormone sites of action and catecholamine sites of production and action in the brain.
性类固醇激素和儿茶酚胺在大脑中存在生理相互作用。通过联合使用放射自显影术和荧光组织化学方法，在同一组织标本中同时观察到了类固醇激素靶位点和儿茶酚胺神经元。通过这种双重定位方法，在脑干中许多儿茶酚胺细胞体的细胞核中鉴定出了[3H]雌二醇和[3H]双氢睾酮的靶位点，并且在某些类固醇激素靶神经元附近观察到了儿茶酚胺神经末梢。这些结果表明，大脑中类固醇激素作用位点与儿茶酚胺产生及作用位点之间存在密切的解剖学相互关系。
