Fraley D S, Bruns F J, Segel D P, Adler S
South Med J. 1980 Feb;73(2):238-40. doi: 10.1097/00007611-198002000-00030.
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension. The bronchospasm was severe in all three and in one patient resulted in respiratory arrest. Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol. Furthermore, each patient was subsequently treated with other antihypertensive medications which, like propranolol, contain the stabilizer additive tartrazine. Bronchospasm did not recur, making it unlikely that tartrazine hypersensitivity caused this problem. Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.
三名无哮喘或过敏史的患者在服用普萘洛尔治疗高血压时发生了支气管痉挛。三名患者的支气管痉挛均很严重，其中一名患者导致呼吸骤停。由于停用普萘洛尔并给予支持性支气管扩张剂治疗后支气管痉挛得到缓解，因此认为支气管痉挛是由普萘洛尔引起的。此外，随后对每名患者使用了其他抗高血压药物进行治疗，这些药物与普萘洛尔一样，都含有稳定剂添加剂酒石黄。支气管痉挛未复发，因此酒石黄过敏不太可能是导致该问题的原因。因此，无论哮喘病史是否为阴性，都必须将危及生命的支气管痉挛视为普萘洛尔治疗可能出现的并发症。
