Hübener K H, Treuner J, Voss A C, Metzger H O
Strahlentherapie. 1980 Jan;156(1):26-9.
In 15 children, combined treatment of the cerebral crane (irradiation + cytostatics) was done for acute leukemia, using Pinkel's or Riehm's method. In order to judge of late sequelae on the brain tissue, the cerebral crane was explored by means of computed tomography, generally more than a year later. Of 15 children 10 revealed slight or important parenchymal alterations being imputable to the former therapy. A possible augmentation of the sensitivity to radiation due to combined chemotherapy is discussed, and a revisal of therapeutic schedules, therefore, is recommended.
对15名儿童采用平克尔（Pinkel）法或里姆（Riehm）法，针对急性白血病进行了颅脑联合治疗（放疗+细胞抑制剂）。为了判断脑组织的晚期后遗症，一般在一年多以后通过计算机断层扫描对颅脑进行检查。15名儿童中有10名显示出轻微或严重的实质性改变，这可归因于先前的治疗。文中讨论了联合化疗可能导致对辐射敏感性增加的情况，因此建议对治疗方案进行修订。
