抗Sdx：一种与Sda血型相关的“新型”自身凝集素。

Anti-Sdx: a "new" auto-agglutinin related to the Sda blood group.

作者信息

Marsh W L, Johnson C L, Oyen R, Nichols M E, DiNapoli J, Young H, Brassel J, Cusumano I, Bazaz G R, Haber J M, Wolf C F

出版信息

Transfusion. 1980 Jan-Feb;20(1):1-8. doi: 10.1046/j.1537-2995.1980.20180125021.x.

DOI:10.1046/j.1537-2995.1980.20180125021.x

Abstract

Two examples of a "new" IgM saline-agglutinating auto-antibody are described. The antibodies bind complement, have the ability to cause in vivo hemolysis, and are most active at room temperature at a pH of about 6.5. Despite tests on more than 5,000 people, no nonreactive cell sample has been found. The reactive antigen is not denatured by neuraminidase, papain, or ficin, and is present on i adult red blood cells. The antibodies appear to be slightly inhibited by human saliva and milk, and more convincingly inhibited by urine from Sd(a+) persons. They are not inhibited by urine from Sd(a-) persons, but are strongly inhibited by guinea pig urine. The serologic characteristics indicate a relationship to the Sda blood group and the auto-antibody has been named antiSdx. Sdx antigen is present on red blood cells from some higher primates and is absent from rabbit, rhesus monkey, dog and sheep cells.

摘要

本文描述了两种“新型”IgM盐水凝集自身抗体的实例。这些抗体可结合补体，具有在体内引起溶血的能力，且在室温下pH约为6.5时活性最强。尽管对5000多人进行了检测，但尚未发现无反应性的细胞样本。反应性抗原不会被神经氨酸酶、木瓜蛋白酶或无花果蛋白酶变性，且存在于成人红细胞上。这些抗体似乎会受到人类唾液和乳汁的轻微抑制，而来自Sd(a+)个体的尿液对其抑制作用更明显。来自Sd(a-)个体的尿液对其无抑制作用，但豚鼠尿液可强烈抑制它们。血清学特征表明其与Sda血型有关，这种自身抗体被命名为抗Sdx。Sdx抗原存在于一些高等灵长类动物的红细胞上，而兔、恒河猴、狗和绵羊的细胞上则没有。