Hartung R, Schmeller M, Mauermayer W, Blümel G
Urologe A. 1980 Jan;19(1):11-22.
Alterations on the upper urinary-tract and on the kidney have been investigated by histology and scanning-electron-microscopy (SEM) in an animal study on the rat. Examinations have been performed 7, 14, 28 and 56 days after double-ligating the ureter. The documentation shows the developed alterations which are remarkable in the area of the papilla and medulla of the kidney, whereas the glomerula are nearly unchanged in comparison with the controls. At the same time function-tests with radioactively labelled Jodium-Hippuran and technetium-DTPA have been performed. The nephrograms in the region of interest technique showed after 14 days isosthenuria and after 4 weeks no signs of any function on the operated side.
在一项针对大鼠的动物研究中，通过组织学和扫描电子显微镜（SEM）对大鼠上尿路和肾脏的改变进行了研究。在双侧输尿管结扎术后7天、14天、28天和56天进行了检查。记录显示所出现的改变在肾乳头和髓质区域较为显著，而与对照组相比，肾小球几乎没有变化。同时，还进行了放射性标记的碘马尿酸和锝-二乙三胺五乙酸的功能测试。感兴趣区域技术的肾图显示，术后14天出现等渗尿，4周后手术侧无任何功能迹象。
