Lorijn R H, Longo L D
Am J Obstet Gynecol. 1980 Feb 15;136(4):451-7. doi: 10.1016/0002-9378(80)90670-5.
In an effect to determine if placental diffusion reserves exceed fetal oxygen requirements we artificially increased fetal O2 consumption by infusing norepinephrine (NE) or triiodothyronine (T3) into 24 chronically catheterized fetal lambs. After 50 minutes of NE infusion, fetal O2 consumption rose 25%; after 5 days of T3 infusion, it increased 28%. In both instances there was a redistribution of organ blood flows, but placental diffusing capacity and the fetal venous and arterial blood gas values remained essentially unchanged. We concluded that both NE and T3 infusion can result in an increased rate of fetal metabolism with increased oxygen consumption and that the placental reserve for O2 diffusion exceeds normal oxygen requirements.
为了确定胎盘扩散储备是否超过胎儿的氧需求，我们通过向24只长期插管的胎羊输注去甲肾上腺素（NE）或三碘甲状腺原氨酸（T3）来人为增加胎儿的耗氧量。输注NE 50分钟后，胎儿耗氧量增加了25%；输注T3 5天后，增加了28%。在这两种情况下，器官血流都发生了重新分布，但胎盘扩散能力以及胎儿静脉和动脉血气值基本保持不变。我们得出结论，输注NE和T3均可导致胎儿代谢率增加，耗氧量增加，且胎盘的氧扩散储备超过正常氧需求。
