精神疾病患者脑脊液中的γ-氨基丁酸水平。
GABA levels in CSF of patients with psychiatric disorders.
作者信息
Gold B I, Bowers M B, Roth R H, Sweeney D W
出版信息
Am J Psychiatry. 1980 Mar;137(3):362-4. doi: 10.1176/ajp.137.3.362.
PMID:7356067
Abstract
The authors measured gamma-aminobutyric acid (GABA) levels in the lumbar CSF of patients with depression, with psychosis, or undergoing evaluation for a neurologic disorder. GABA levels in the CSF from depressed patients were significantly decreased compared with neurologic control patients. CSF GABA levels in psychotic patients were not different from those in neurologic patients, although the data suggested a decrease in CSF GABA levels in patients with schizoaffective disorder.
摘要
作者测量了患有抑郁症、精神病或正在接受神经系统疾病评估的患者腰椎脑脊液中的γ-氨基丁酸（GABA）水平。与神经系统对照患者相比，抑郁症患者脑脊液中的GABA水平显著降低。精神病患者脑脊液中的GABA水平与神经系统疾病患者的无异，尽管数据表明精神分裂症情感障碍患者的脑脊液GABA水平有所下降。
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