Jick H, Walker A M, Rothman K J
Am J Public Health. 1980 Mar;70(3):264-7. doi: 10.2105/ajph.70.3.264.
Vital statistics show that a rise in incidence of endometrial cancer began in the mid-1960s on the West Coast of the United States. This rise was continuous and reached a peak in 1975. Elsewhere, incidence rates for endometrial cancer rose during the 1970s. It now seems evident that much of the rise in all areas of the country was due to replacement estrogen treatment. We estimated from data obtained from the Commission on Professional and Hospital Activities-Professional Activity Study of Ann Arbor, Michigan, that over 15,000 cases of endometrial cancer were caused by replacement estrogens during the five-year period 1971--1975 alone. This represents one of the largest epidemics of serious iatrogenic disease that has ever occurred in this country. With the substantial fall in estrogen sales starting in January 1976, there has been an associated decline in the incidence rates of endometrial cancer nationwide.
生命统计数据显示，美国西海岸子宫内膜癌的发病率自20世纪60年代中期开始上升。这种上升持续不断，并在1975年达到峰值。在其他地区，20世纪70年代子宫内膜癌的发病率也有所上升。现在看来很明显，该国所有地区发病率的大幅上升很大程度上是由于替代雌激素治疗。我们根据从密歇根州安阿伯市专业与医院活动委员会——专业活动研究中获得的数据估计，仅在1971年至1975年的五年期间，就有超过15000例子宫内膜癌病例是由替代雌激素引起的。这是该国有史以来发生的最大规模的严重医源性疾病流行之一。随着1976年1月开始雌激素销量大幅下降，全国范围内子宫内膜癌的发病率也随之下降。
