Gruener N, Lockwood M P
Am J Public Health. 1980 Mar;70(3):276-8. doi: 10.2105/ajph.70.3.276.
Drinking water samples concentrated by freeze drying were found to be mutagenic in a mammalian tissue culture assay using Chinese hamster embryonic lung cells (V79). The mutagenicity could be enhanced by the promoter 12-O-tetradecanoyl-phorbol-13-acetate. The water itself was also shown to contain promoting chemicals. The mutation frequency of cells pretreated with low levels of benzo(a)pyrene was increased following subsequent exposure to the concentrated water sample. Approaches to estimate the risk involved in exposure to present drinking water are proposed.
通过冷冻干燥浓缩的饮用水样本，在用中国仓鼠胚胎肺细胞（V79）进行的哺乳动物组织培养试验中被发现具有致突变性。促癌剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯可增强这种致突变性。水本身也被证明含有促癌化学物质。先用低水平苯并(a)芘预处理的细胞，在随后接触浓缩水样后，其突变频率增加。文中提出了评估接触当前饮用水所涉及风险的方法。
