Gruener N, Lockwood M P
J Toxicol Environ Health. 1979 Jul;5(4):663-70. doi: 10.1080/15287397909529778.
Increased use of contaminated water and long-range plans for the direct use of recycled water necessitate a careful assessment of the potential health effect on the population. Selected in vitro assays were used to evaluate the mutagenic and carcinogenic potential of a concentrated, recycled water sample. It was found that the concentrated water induced mutagenicity in hamster lung cells and cellular transformation in human embryonic lung fibroblasts. The use of in vitro analyses in conjunction with epidemiologic studies in determining the human risks of environmental carcinogens is discussed.
受污染水使用的增加以及直接使用再生水的长期规划，使得有必要仔细评估对人群的潜在健康影响。采用选定的体外试验来评估一份浓缩再生水样本的致突变性和致癌潜力。结果发现，浓缩水可诱导仓鼠肺细胞发生致突变性，并使人类胚胎肺成纤维细胞发生细胞转化。本文还讨论了在确定环境致癌物对人类的风险时，将体外分析与流行病学研究结合使用的情况。
