[苯二氮䓬类药物对人血清白蛋白、血红蛋白及红细胞膜空壳中色氨酸荧光的影响]
[Effect of benzodiazepines on the fluorescence of tryptophan in human serum albumin, hemoglobin and erythrocyte ghosts].
作者信息
Terhaag B, Ackermann E
出版信息
Acta Biol Med Ger. 1978;37(3):387-91.
The binding of chlorodiazepoxide, demethyl-chlorodiazepoxide, demoxepam, medazepam, diazepam and oxazepam was investigated on human serum albumin (HSA), ghosts and hemoglobin by quenching the fluorescence of tryptophan. The tryptophan fluorescence is quenched in a dose-dependent manner by these benzodiazepines with the exception of demoxepan, diazepam and oxazepam on hemoglobin. The calculated binding constants are in the range of 10(4)1 . M-1. It is concluded from the quenching of tryptophan-fluorescence that benzodiazepines are bound in a tryptophan containing area of the proteins.
通过淬灭色氨酸荧光，研究了氯氮卓、去甲基氯氮卓、地莫西泮、美达西泮、地西泮和奥沙西泮与人血清白蛋白（HSA）、血影和血红蛋白的结合情况。除地莫西泮、地西泮和奥沙西泮与血红蛋白的结合外，这些苯二氮䓬类药物均以剂量依赖性方式淬灭色氨酸荧光。计算得到的结合常数在10⁴ 1. M⁻¹范围内。从色氨酸荧光淬灭得出的结论是，苯二氮䓬类药物结合在蛋白质中含色氨酸的区域。
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