前激肽释放酶缺乏血浆中依赖因子XII的纤溶酶原激活剂缺乏。
Deficiency of factor XII-dependent plasminogen proactivator in prekallikrein-deficient plasma.
作者信息
Bouma B N, Griffin J H
出版信息
J Lab Clin Med. 1978 Jan;91(1):148-55.
PMID:73563
Abstract
Normal human plasma contains a factor XII (Hageman factor)-dependent plasminogen proactivator in its gamma globulin fraction. On the basis of both fibrin plate and clot lysis assays, this plasminogen proactivator activity was shown to be absent from the gamma globulin fraction of prekallikrein (Fletcher factor)-deficient plasma of two unrelated patients. This observation suggests that factor XII-dependent plasminogen proactivator is identical to plasma prekallikrein.
摘要
正常人体血浆在其γ球蛋白部分含有一种依赖于因子Ⅻ（哈格曼因子）的纤溶酶原激活剂。基于纤维蛋白平板和凝块溶解试验，两名无关患者的前激肽释放酶（弗莱彻因子）缺乏血浆的γ球蛋白部分均显示缺乏这种纤溶酶原激活剂活性。这一观察结果表明，依赖于因子Ⅻ的纤溶酶原激活剂与血浆前激肽释放酶相同。
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