Poh-Fitzpatrick M B, Masullo A S, Grossman M E
Arch Dermatol. 1980 Feb;116(2):191-5.
A fourth case of symptomatic porphyria associated with hemodialysis for chronic renal failure is reported. Subepidermal bullous dermatoses of patients who have undergone hemodialysis have not usually been associated with elevated porphyrin levels. However, this patient and three previously reported cases have been found to have abnormal porphyrin study results in association with skin lesions typical for porphyria cutanea tarda, occurring after hemodialysis. Hemodialysis does not effectively decrease circulating plasma uroporphyrin levels, although some dialysis of uroporphyrin into the dialysate could be measured in this case. Evaluation of bullous or porphyrialike dermatoses in patients treated with hemodialysis should include adequate testing for increased porphyrin levels.
报告了第四例与慢性肾衰竭血液透析相关的症状性卟啉病。接受血液透析患者的表皮下大疱性皮肤病通常与卟啉水平升高无关。然而，该患者及之前报道的三例患者在血液透析后出现了与迟发性皮肤卟啉病典型皮肤病变相关的异常卟啉研究结果。尽管在该病例中可检测到一些尿卟啉透析进入透析液，但血液透析并不能有效降低循环血浆中尿卟啉水平。对接受血液透析治疗的患者出现的大疱性或类卟啉性皮肤病进行评估时，应包括对卟啉水平升高进行充分检测。
