Kula K, Romer T E, Wlodarczyk W P
Arch Androl. 1980 Feb;4(1):9-16. doi: 10.3109/01485018008988274.
Certain successive phases of seminiferous tubule maturation were observed in a transsection of a Leydig cell adenoma-bearing testis of a boy with precocious puberty. Massively accumulated Leydig cells may stimulate the maturation of Sertoli cells, as indicated by progressive replacement of Sertoli cell precursors by mature Sertoli cells at a distance closer to the adenoma. On the other hand, tubules less advanced in maturation contained a higher number of somatic cells than those more advanced in maturation. Leydig-cell-dependent maturation of Sertoli cells may be in competition with Certoli cell multiplication, or numerous undifferentiated somatic cells may undergo a natural elimination in the course of tubular maturation. An inverse relation between the number of Sertoli cell precursors and the number of meiotic spermatocytes suggests that quantitative reduction of Sertoli cell precursors may be important for the intratubular milieu necessary for the onset of the first meiosis in man.
在一名性早熟男孩的患有莱迪希细胞瘤的睾丸横切面上，观察到了生精小管成熟的某些连续阶段。大量积聚的莱迪希细胞可能会刺激支持细胞的成熟，这表现为在距离腺瘤较近的位置，支持细胞前体逐渐被成熟支持细胞所取代。另一方面，成熟程度较低的小管比成熟程度较高的小管含有更多的体细胞。莱迪希细胞依赖的支持细胞成熟可能与支持细胞增殖相互竞争，或者大量未分化的体细胞可能在小管成熟过程中自然消除。支持细胞前体数量与减数分裂期精母细胞数量之间的反比关系表明，支持细胞前体数量的定量减少对于人类第一次减数分裂开始所需的小管内环境可能很重要。
