一种溶血效率降低的小鼠C4分子。
A murine C4 molecule with reduced hemolytic efficiency.
作者信息
Atkinson J P, McGinnis K, Brown L, Peterein J, Shreffler D
出版信息
J Exp Med. 1980 Feb 1;151(2):492-7. doi: 10.1084/jem.151.2.492.
Abstract
C4 functional activity and antigenic levels were determined in H-2-congenic mouse strains. In strains with the H-2w7 haplotype, the C4 hemolytic activity per unit of residual Ss antigenic activity, after depletion of the nonfunctional Slp-positive molecules was 25-33% that found with other H-2 haplotypes. This reduced hemolytic efficiency was not the result of either a more labile C4 molecule or of the presence of inhibitors. Moreover, other strains with comparable antigenic concentrations of Ss (C4) and Slp has three- to fourfold higher levels of C4 hemolytic activity. Based on these data and previously reported structural differences between C4 molecules from the H-2w7 haplotype compared with other standard H-2 haplotypes, the reduced hemolytic efficiency of this molecule is probably secondary to alterations in the structure of its alpha-chain.
摘要
在H-2同源基因小鼠品系中测定了C4功能活性和抗原水平。在具有H-2w7单倍型的品系中，去除无功能的Slp阳性分子后，每单位残余Ss抗原活性的C4溶血活性是其他H-2单倍型的25%-33%。这种溶血效率降低并非更不稳定的C4分子或存在抑制剂所致。此外，具有相当抗原浓度的Ss（C4）和Slp的其他品系，其C4溶血活性水平高三到四倍。基于这些数据以及先前报道的与其他标准H-2单倍型相比，来自H-2w7单倍型的C4分子之间的结构差异，该分子溶血效率降低可能是其α链结构改变的继发结果。
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本文引用的文献
1
Enhancement of hemolytic complement activity by treatment of human serum with iodine.用碘处理人血清增强溶血补体活性。
J Immunol. 1971 Nov;107(5):1493-5.
2
Hemolytic efficiencies of genetic variants of human C3.
J Immunol. 1972 May;108(5):1184-7.
3
The relationship of glycine-rich -glycoprotein to factor B in the properdin system and to the cobra factor-binding protein of huan serum.富含甘氨酸的糖蛋白与备解素系统中的B因子以及人血清眼镜蛇因子结合蛋白的关系。
J Exp Med. 1973 Feb 1;137(2):424-37. doi: 10.1084/jem.137.2.424.
4
The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.组织相容性-2连锁的Ss-Slp区域在小鼠补体控制中的作用。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):863-4. doi: 10.1073/pnas.70.3.863.
5
6
Hereditary angioedema: the clinical syndrome and its management.遗传性血管性水肿：临床综合征及其管理
Ann Intern Med. 1976 May;84(5):580-93. doi: 10.7326/0003-4819-84-5-580.
7
H-2 linked Ss protein is C4 component of complement.与H-2连锁的Ss蛋白是补体的C4成分。
Nature. 1975 Nov 20;258(5532):243-5. doi: 10.1038/258243a0.
8
Identification of Ss protein as murine C4.鉴定 Ss 蛋白为小鼠 C4。
Nature. 1975 Nov 20;258(5532):242-3. doi: 10.1038/258242a0.
9
Genetics of the complement system.补体系统的遗传学
Adv Hum Genet. 1976;7:141-88. doi: 10.1007/978-1-4757-0659-8_4.
10
The S region of the mouse major histocompatibility complex (H-2): genetic variation and functional role in complement system.小鼠主要组织相容性复合体（H-2）的S区域：补体系统中的遗传变异及功能作用
Transplant Rev. 1976;32:140-67. doi: 10.1111/j.1600-065x.1976.tb00232.x.
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