口服可待因和异丙嗪对人类志愿者二氧化碳通气反应影响的性别差异。
A sex difference in the effects of oral codeine and promethazine on the ventilatory response to carbon dioxide in human volunteers.
作者信息
Pleuvry B J, Maddison S E
出版信息
Br J Clin Pharmacol. 1980 Feb;9(2):159-64. doi: 10.1111/j.1365-2125.1980.tb05827.x.
Abstract
1 Interactions between codeine and promethazine have been studied in male and female volunteers, measuring ventilation, end tidal PCO2, ventilatory response to CO2, pulse and blood pressure. 2 The effects of codeine on the above measurements have been compared in subjects who habitually smoke cigarettes and non smoking subjects. 3 Codeine displaced the ventilatory response to CO2 to the right and increased end tidal PCO2 in female subjects but not in males. 4 Promethazine plus codeine displaced the ventilatory response to CO2 to the right in male subjects but tended to reduce the response to codeine in females. 5 The slope of the ventilatory response to CO2 was significantly steeper in smokers and codeine caused significant reductions in slope in these subjects.
摘要
- 已在男性和女性志愿者中研究了可待因与异丙嗪之间的相互作用，测量了通气、呼气末二氧化碳分压、对二氧化碳的通气反应、脉搏和血压。2. 比较了习惯性吸烟者和非吸烟者中可待因对上述测量指标的影响。3. 可待因使女性受试者对二氧化碳的通气反应右移，并增加了呼气末二氧化碳分压，但男性受试者未出现这种情况。4. 异丙嗪加可待因使男性受试者对二氧化碳的通气反应右移，但倾向于降低女性受试者对可待因的反应。5. 吸烟者对二氧化碳的通气反应斜率明显更陡，可待因使这些受试者的斜率显著降低。
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