神经节苷脂与花生凝集素、血清素和柔红霉素相互作用的差示扫描量热法研究

A differential scanning calorimetry study of the interaction of gangliosides with peanut lectin, serotonin and daunomycin.

作者信息

Bach D, Sela B A

出版信息

Biochim Biophys Acta. 1980 Feb 28;596(2):186-91. doi: 10.1016/0005-2736(80)90353-3.

Abstract

Thermotropic behaviour of human Tay-Sachs ganglioside and of mixed bovine brain gangliosides, before and after interaction with peanut lectin, serotonin and daunomycin, was investigated. Interaction of mixed brain gangliosides with peanut lectin or serotonin causes a decrease in the enthalpy of melting, whereas interaction of this lectin with Tay-Sachs ganglioside does not influence the enthalpy of melting. Serotonin causes a small increase in the enthalpy of melting of the Tay-Sachs ganglioside.

摘要

研究了人泰-萨克斯神经节苷脂以及混合牛脑神经节苷脂在与花生凝集素、血清素和柔红霉素相互作用之前和之后的热致行为。混合脑神经节苷脂与花生凝集素或血清素的相互作用导致熔化焓降低，而这种凝集素与泰-萨克斯神经节苷脂的相互作用不影响熔化焓。血清素使泰-萨克斯神经节苷脂的熔化焓略有增加。