Pass H L, Klorman R, Salzman L F, Klein R H, Kaskey G B
Biol Psychiatry. 1980 Feb;15(1):9-20.
To investigate the relationship between behavioral and cortical measures of impaired attention in schizophrenia, 17 hospitalized acute schizophrenics and 16 hospitalized nonpsychotic patients were studied. Event-related potentials (ERP) were obtained while subjects performed the Continuous Performance Test (CPT) under three conditions: First base line, Auditory-Visual Distraction, and Second base line. Schizophrenics made more errors of omission and commission and had longer reaction times. Analysis of the Late Positive Component (LPC) of the ERP revealed that both groups had an attenuated LPC during distraction and a larger LPC to the critical compared to the noncritical stimulus throughout all conditions. Schizophrenics had a smaller LPC and a smaller amplitude difference between the critical and noncritical stimulus than the nonpsychotics throughout all conditions.
为了研究精神分裂症患者注意力受损的行为和皮层测量指标之间的关系，对17名住院急性精神分裂症患者和16名住院非精神病患者进行了研究。在三种条件下，即首次基线、视听干扰和第二次基线，让受试者执行连续作业测试（CPT）时记录事件相关电位（ERP）。精神分裂症患者出现更多的漏报和误报错误，且反应时间更长。对ERP的晚期正成分（LPC）分析显示，在所有条件下，两组在干扰期间LPC均减弱，与非关键刺激相比，对关键刺激的LPC更大。在所有条件下，精神分裂症患者的LPC较小，关键刺激和非关键刺激之间的振幅差异也小于非精神病患者。
