Whall C W, Myers M M, Halpern W
Blood Vessels. 1980;17(1):1-15. doi: 10.1159/000158230.
Intact segments of mesenteric resistance arteries (200 micron) from 5-month-old spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats were tested for norepinephrine (NE) sensitivity. Dose-response curves were obtained both before and after adrenergic denervation produced by short-term, in vitro, 6-hydroxydopamine (6-OHDA) treatment. NE sensitivities of innervated vessels were the same in SHR and WKY rats, however, after 6-OHDA, not only did both ED50s show significant decreases (8.7- and 3.8-fold, respectively), but the ED50 of SHR vessels was half that of WKY (NE sensitivity increased twofold). In addition there was a 33% increase in wall tension generated in response to maximum NE stimulation, and a 44% increase in neuronal NE uptake in the SHR vessels. These results show that several important alterations have occurred in resistance vessels from SHR rats in the established phase of hypertension. The relationship of the increase in neuronal uptake to the increased total peripheral resistance and increased vascular reactivity commonly seen in SHR perfused beds and whole animals is unknown. However, the increase in NE sensitivity and in maximum NE wall tension could contribute to increase in both of these characteristics.
对5月龄自发性高血压大鼠（SHR）和血压正常的Wistar Kyoto大鼠（WKY）肠系膜阻力动脉（200微米）的完整节段进行去甲肾上腺素（NE）敏感性测试。在通过短期体外6-羟基多巴胺（6-OHDA）处理产生肾上腺素能去神经支配之前和之后，均获得了剂量反应曲线。在SHR和WKY大鼠中，受神经支配血管的NE敏感性相同，然而，在6-OHDA处理后，不仅两者的半数有效剂量（ED50）均显著降低（分别降低8.7倍和3.8倍），而且SHR血管的ED50是WKY的一半（NE敏感性增加了两倍）。此外，在最大NE刺激下，SHR血管产生的壁张力增加了33%，神经元NE摄取增加了44%。这些结果表明，在高血压的既定阶段，SHR大鼠的阻力血管发生了一些重要变化。神经元摄取增加与SHR灌注床和整个动物中常见的总外周阻力增加和血管反应性增加之间的关系尚不清楚。然而，NE敏感性和最大NE壁张力的增加可能导致这两个特征的增加。
