一种依赖钙的乙酰胆碱去极化作用，在蜗牛神经元中被甲氧基维拉帕米（D600）和普鲁卡因阻断。
A calcium-dependent acetylcholine depolarization blocked by methoxyverapamil (D600) and procaine in snail neurones.
作者信息
Israel J M, Meunier J M
出版信息
Br J Pharmacol. 1980 Feb;68(2):235-40. doi: 10.1111/j.1476-5381.1980.tb10412.x.
Abstract
1 Repetitive application of acetylcholine (ACh) revealed two types of ACh depolarization in two types of snail neurone, depending on their desensitization properties. 2 Further experiments were carried out on neurones which displayed a rapidly desensitizing response. 3 The amplitude of the response depended on the external sodium and calcium levels. 4 Procaine antagonized ACh effects with the same efficiency as atropine or hexamethonium, half maximal depression being obtained at a concentration of 10(-4) M. The blocking effect was independent of the dose of ACh. 5 The depression of the ACh-induced depolarization by cobalt ions and D600 suggests that calcium may participate in this response.
摘要
- 重复施加乙酰胆碱（ACh）后发现，根据两种蜗牛神经元的脱敏特性，存在两种类型的ACh去极化。2. 对表现出快速脱敏反应的神经元进行了进一步实验。3. 反应的幅度取决于细胞外钠和钙的水平。4. 普鲁卡因拮抗ACh作用的效率与阿托品或六甲铵相同，在浓度为10（-4）M时可产生半数最大抑制。阻断作用与ACh的剂量无关。5. 钴离子和D600对ACh诱导的去极化的抑制作用表明钙可能参与了这一反应。
相似文献
1
A calcium-dependent acetylcholine depolarization blocked by methoxyverapamil (D600) and procaine in snail neurones.一种依赖钙的乙酰胆碱去极化作用，在蜗牛神经元中被甲氧基维拉帕米（D600）和普鲁卡因阻断。
Br J Pharmacol. 1980 Feb;68(2):235-40. doi: 10.1111/j.1476-5381.1980.tb10412.x.
2
Procaine as an acetylcholine agonist in snail neuron.普鲁卡因作为蜗牛神经元中的一种乙酰胆碱激动剂。
J Pharmacol Exp Ther. 1979 Oct;211(1):93-8.
3
[The action of alpha-bungarotoxin on the acetylcholine responses of the membrane of snail neurons].
Neirofiziologiia. 1989;21(6):729-35.
4
Acetylcholine-induced hyperpolarization in identified neurones of the African giant snail (Achatina fulica Férussac).
Brain Res. 1986 May 28;374(2):227-35. doi: 10.1016/0006-8993(86)90416-6.
5
Effect of "calcium antagonist" D-600 on the postsynaptic membrane.“钙拮抗剂”D - 600对突触后膜的作用。
J Physiol (Paris). 1980 Sep;76(5):515-22.
6
The effect of acetylcholine and serotonin on calcium transients and calcium currents in identified Helix pomatia L. neurons.乙酰胆碱和血清素对鉴定出的苹果螺神经元中钙瞬变和钙电流的影响。
Cell Signal. 1994 Jul;6(5):551-9. doi: 10.1016/0898-6568(94)90009-4.
7
D600 as a direct blocker of Ca-dependent K currents in Helix neurons.D600作为螺旋神经元中钙依赖性钾电流的直接阻滞剂。
Eur J Pharmacol. 1985 Nov 19;117(3):311-22. doi: 10.1016/0014-2999(85)90004-4.
8
The mode of action of antagonists of the excitatory response to acetylcholine in Aplysia neurones.海兔神经元中乙酰胆碱兴奋性反应拮抗剂的作用模式。
J Physiol. 1978 May;278:207-35. doi: 10.1113/jphysiol.1978.sp012300.
9
Effects of compound D600 (methoxyverapamil) on drug-induced contractions of isolated dog uterine muscle.化合物D600（甲氧维拉帕米）对药物诱导的离体犬子宫肌收缩的影响。
Gen Pharmacol. 1986;17(2):203-9. doi: 10.1016/0306-3623(86)90140-0.
10
Roles of stored calcium on the mechanical response evoked in smooth muscle cells of the porcine coronary artery.储存钙在猪冠状动脉平滑肌细胞诱发的机械反应中的作用。
J Physiol. 1982 Jan;322:107-25. doi: 10.1113/jphysiol.1982.sp014026.
引用本文的文献
1
Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockers in vitro.
J Neural Transm. 1985;64(3-4):285-93. doi: 10.1007/BF01256473.
2
The role of cGMP in the extinction of the reactions of identified neurons of the edible snail in response to acetylcholine.环磷酸鸟苷（cGMP）在可食用蜗牛特定神经元对乙酰胆碱反应消退中的作用。
Neurosci Behav Physiol. 1990 Jul-Aug;20(4):323-30. doi: 10.1007/BF01236326.
本文引用的文献
1
Cholinergic transmission mechanisms for both excitation and inhibition in molluscan central synapses.软体动物中枢突触中兴奋和抑制的胆碱能传递机制。
Nature. 1961 Oct 28;192:366-7. doi: 10.1038/192366a0.
2
Properties of the procaine end-plate potential.普鲁卡因终板电位的特性。
Jpn J Physiol. 1957 Sep 30;7(3):199-212. doi: 10.2170/jjphysiol.7.199.
3
A study of curare action with an electrical micromethod.一项用电学微方法进行的箭毒作用研究。
Proc R Soc Lond B Biol Sci. 1957 May 7;146(924):339-56. doi: 10.1098/rspb.1957.0015.
4
Competitive action of calcium and procaine on lobster axon. A study of the mechanism of action of certain local anesthetics.钙和普鲁卡因对龙虾轴突的竞争性作用。某些局部麻醉药作用机制的研究。
J Gen Physiol. 1966 May;49(5):1043-63. doi: 10.1085/jgp.49.5.1043.
5
The effect of atropine on the frog sartorius neuromuscular junction.阿托品对青蛙缝匠肌神经肌肉接头的作用。
J Physiol. 1968 Mar;195(2):493-503. doi: 10.1113/jphysiol.1968.sp008470.
6
Effects of manganese and other agents on the calcium uptake that follows depolarization of squid axons.锰及其他试剂对鱿鱼轴突去极化后钙摄取的影响。
J Physiol. 1973 Jun;231(3):511-26. doi: 10.1113/jphysiol.1973.sp010246.
7
A kinetic model for the action of xylocaine on receptors for acetylcholine.关于利多卡因作用于乙酰胆碱受体的动力学模型。
J Gen Physiol. 1968 Jul;52(1):162-80. doi: 10.1085/jgp.52.1.162.
8
The effect of atropine on acetylcholine action at the neuromuscular junction.阿托品对神经肌肉接头处乙酰胆碱作用的影响。
Proc R Soc Lond B Biol Sci. 1973 Nov 27;184(1075):221-6. doi: 10.1098/rspb.1973.0046.
9
The effect of procaine on the action of acetylcholine at the neuromuscular junction.普鲁卡因对乙酰胆碱在神经肌肉接头处作用的影响。
J Physiol. 1975 Jul;249(2):269-84. doi: 10.1113/jphysiol.1975.sp011015.
10
Noise and relaxation studies of acetylcholine induced currents in the presence of procaine.在普鲁卡因存在的情况下乙酰胆碱诱导电流的噪声与弛豫研究
J Physiol. 1978 May;278:237-50. doi: 10.1113/jphysiol.1978.sp012301.
Zotero 插件