Sima A A, Robertson D M
Acta Neuropathol. 1978 Dec 15;44(3):189-95. doi: 10.1007/BF00691066.
The permeabilities of the blood-nerve barrier and the perineurial barrier were investigated in alloxan and streptozotocin diabetic rats and in the mutant diabetic mouse [C57BL/Ks(db/db)]. In the mouse model both fluorescence and electron microscopic techniques were employed using Evans blue albumin (EBA) and horseradish peroxidase (HRP), respectively, as exogeneous tracers. In the rat models only HRP was used. Tracers were applied locally around the sciatic nerve in order to investigate the perineurial barrier, and systemically to detect changes in the blood nerve barrier. None of the models was found to show increased permeability across either of the barriers.
在四氧嘧啶和链脲佐菌素诱导的糖尿病大鼠以及突变型糖尿病小鼠[C57BL/Ks(db/db)]中，研究了血神经屏障和神经束膜屏障的通透性。在小鼠模型中，分别使用伊文思蓝白蛋白（EBA）和辣根过氧化物酶（HRP）作为外源性示踪剂，采用荧光和电子显微镜技术。在大鼠模型中仅使用了HRP。将示踪剂局部应用于坐骨神经周围，以研究神经束膜屏障，并进行全身给药以检测血神经屏障的变化。未发现任何模型中两种屏障的通透性增加。
