Dhital K, Lincoln J, Appenzeller O, Burnstock G
Brain Res. 1986 Mar 5;367(1-2):39-44. doi: 10.1016/0006-8993(86)91576-3.
Adrenergic nerves were studied in nervi nervorum and perivascular nerve plexus of vasa nervorum in whole-mount nerve sheath preparations of optic, sciatic and vagus nerves and in the paravertebral sympathetic chain in normal and streptozotocin-treated diabetic rats. A substantial or complete loss of fluorescent adrenergic fibres around blood vessels in the optic nerves was observed 8 weeks after induction of diabetes. This was in marked contrast to the increase in perivascular adrenergic fibres in the sciatic, vagus and sympathetic chain nerve trunks of the same animals at the same time. Assays of noradrenaline levels in whole nerve segments also showed that they were not biochemically detectable in the optic nerves but were significantly higher in the vagus of diabetic animals (P less than 0.05). There was also an increase in numbers of mast cells in the vicinity of vasa nervorum of diabetic nerves.
在正常大鼠和经链脲佐菌素治疗的糖尿病大鼠的视神经、坐骨神经和迷走神经的全层神经鞘制剂以及椎旁交感神经链的神经束膜神经和血管神经周围神经丛中，对肾上腺素能神经进行了研究。糖尿病诱导8周后，观察到视神经血管周围荧光肾上腺素能纤维大量或完全丧失。这与同一动物同期坐骨神经、迷走神经和交感神经链神经干中血管周围肾上腺素能纤维的增加形成明显对比。对整个神经节段去甲肾上腺素水平的测定还表明，在视神经中无法通过生化方法检测到去甲肾上腺素，但在糖尿病动物的迷走神经中，其水平显著升高（P<0.05）。糖尿病神经的血管神经周围肥大细胞数量也有所增加。
