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手术治疗骨折后骨髓炎。62例采用根治性手术及林可霉素(洁霉素)治疗的报告。

Osteomyelitis after operative fracture treatment. A report of 62 cases treated with radical surgery and lincomycin (Lincocin).

作者信息

Hagen R

出版信息

Acta Orthop Scand. 1978 Dec;49(6):542-8. doi: 10.3109/17453677808993235.

Abstract

During the years 1967--1975 a total of 62 patients were treated for postoperative osteomyelitis. The lower extremities had been fractured in 89 per cent of the cases and 54 per cent were closed injuries. The fractures, mostly caused by traffic accidents and falls, had been immobilized by plates in 30 and by intramedullary nails or pins in 25 patients. Staphylococcus aureus was cultured in 80 per cent, 68 per cent of them were resistant to penicillin, but in 84 per cent the organisms were highly lincomycin sensitive and only three patients with four osteomyelitic lesions presented lincomycin resistance. The treatment consisted chiefly of sequestrectomies and saucerizations supported by 3--12 months of lincomycin treatment. In 30 operations a closed irrigation-suction technique was used, perfusing the wound with lincomycin solution. Stable implants should be left in place until the fracture is clinically solid whereas unstable osteosyntheses should be replaced by rigid internal or extraskeletal fixation. At follow-up, the results were judged as good in 74 per cent, fair 8 per cent and poor 18 per cent. The amputation rate was 13 per cent. Plates should not be used in the treatment of comminuted tibial fractures with considerable soft tissue damage.

摘要

1967年至1975年期间,共有62例患者接受了术后骨髓炎的治疗。其中89%的病例下肢骨折,54%为闭合性损伤。骨折大多由交通事故和跌倒所致,30例患者采用钢板固定,25例患者采用髓内钉或钢针固定。80%的病例培养出金黄色葡萄球菌,其中68%对青霉素耐药,但84%的菌株对林可霉素高度敏感,仅有3例患者的4处骨髓炎病灶对林可霉素耐药。治疗主要包括死骨切除术和碟形手术,并辅以3至12个月的林可霉素治疗。30例手术采用闭合冲洗吸引技术,用林可霉素溶液灌注伤口。稳定的内固定物应保留至骨折临床愈合,而不稳定的骨固定术则应更换为坚强的内固定或外固定。随访时,74%的结果评定为良好,8%为一般,18%为差。截肢率为13%。对于伴有严重软组织损伤的粉碎性胫骨骨折,不应使用钢板治疗。

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