Ali M K, Mountain C F, Ewer M S, Johnston D, Haynie T P
Chest. 1980 Mar;77(3):337-42. doi: 10.1378/chest.77.3.337.
Studies of regional pulmonary function using radioactive 133xenon gas and spirometric tests (forced vital capacity and forced expiratory volume in the first second) were performed before and after unilateral pulmonary resection for cancer of the lung. Ninety-one patients were evaluated; 47 underwent total pneumonectomy, and 44 underwent lobectomy. The postoperative serial evaluations were classified into short-term and long-term studies (less than or more than three months, respectively). The preoperative and postoperative data were utilized to derive formulas for predicting an estimate of the overall functional loss after pulmonary resection based on the number of segments removed. The correlation between the predicted and measured postoperative values was good for resections involving more than three segments (r = 0.83). Prediction for smaller resections was unreliable. While both regional and overall pulmonary functions were relatively stable after pneumonectomy, there was a disproportionate early loss, followed by significant functional improvement with time following lobectomy. The anticipation of and preparation for this early loss of function may be crucial in the treatment of these patients.
在单侧肺癌肺切除术前和术后，使用放射性133氙气和肺量计测试（用力肺活量和第1秒用力呼气量）对局部肺功能进行了研究。共评估了91例患者；47例行全肺切除术，44例行肺叶切除术。术后连续评估分为短期和长期研究（分别为少于或多于三个月）。利用术前和术后数据得出公式，以根据切除的肺段数量预测肺切除术后总体功能损失的估计值。对于涉及三个以上肺段的切除术，预测值与术后测量值之间的相关性良好（r = 0.83）。对于较小切除术的预测不可靠。全肺切除术后局部和总体肺功能相对稳定，但肺叶切除术后早期功能损失不成比例，随后随着时间推移功能有显著改善。对这种早期功能损失的预期和准备在这些患者的治疗中可能至关重要。
