Werner G, Morgenstern E
Eur J Cell Biol. 1980 Feb;20(3):276-82.
The typical reconstruction model of an unstimulated human platelet is presented. It shows a strict spatial order of organelles and enodmembrane systems. The surface-connected vesicle system is predominantly found in the periphery. The dense tubules constitute a continuous, interconnected system found just under the surface of the platelet. They are particularly pronounced in the vicinity of the marginal microtubules. All organelles are in contact with the dense tubular system (DTS). Granules, vesicles and plasmalemma fuse into the tubules. The platelet organelles are centrally located. Lysosomal granules are primarily shperical and all of them contain a nucleoid. This speaks in favor of a single type of storage organelle in the platelet. The dense bodies and their remnants (large, solitary vesicles) are not joined by the other endomembrane systems, as in the case of the granules. A particular pathways for the release of substances from these organelles is now morphologically plausible. Mitochondria are small, solitary granules surrounded by dense tubules. Owing to its unique position with the platelet, the DTS's role as a mediating and regulatory structure is discussed.
本文展示了未受刺激的人类血小板的典型重建模型。它显示了细胞器和内膜系统的严格空间顺序。表面连接的囊泡系统主要位于周边。致密小管构成了一个连续的、相互连接的系统，位于血小板表面下方。它们在边缘微管附近尤为明显。所有细胞器都与致密小管系统（DTS）接触。颗粒、囊泡和质膜融合到小管中。血小板细胞器位于中央。溶酶体颗粒主要呈球形，所有颗粒都含有一个类核。这表明血小板中存在单一类型的储存细胞器。致密体及其残余物（大的、单个的囊泡）不像颗粒那样与其他内膜系统相连。现在从形态学上看，这些细胞器释放物质的特定途径是合理的。线粒体是被致密小管包围的小的、单个的颗粒。由于其在血小板中的独特位置，讨论了DTS作为介导和调节结构的作用。
