Williams G T, Arthur J F, Bussey H J, Morson B C
Histopathology. 1980 Mar;4(2):155-70. doi: 10.1111/j.1365-2559.1980.tb02909.x.
Five hundred and fifty-four colorectal metaplastic polyps have been studied histologically. Whilst most lesions were small and sessile, 16.1% measured greater than 0.5 cm in diameter and 0.9% were greater than 1 cm. The larger polyps were frequently pedunculated and occasionally showed a tubulo-villous or villous pattern. A structural similarity between the larger metaplastic polyps and colorectal adenomas is illustrated and the importance of the distinction of metaplastic from dysplastic epithelium in the differentiation of these lesions is stressed. Other unusual features of metaplastic polyps are described. Evidence is given to suggest that males have a greater propensity to develop metaplastic polyps than females. A search for men adenomas, but relatively frequent (20.8%) in juvenile polyps. Finally, seven patients with multiple metaplastic polyps of the colorectum are described, in whom a diagnosis of adenomatous polyposis had been made at some stage in their management. Six of the seven patients were males and the mean age at presentation was 37.4 years. Larger metaplastic polyps were frequent in these cases. The necessity for histological confirmation in all cases of intestinal polyposis is stressed, and the possibility that 'metaplastic polyposis' is a pathological entity is discussed.
对554例大肠化生息肉进行了组织学研究。虽然大多数病变较小且无蒂，但16.1%的病变直径大于0.5 cm，0.9%的病变直径大于1 cm。较大的息肉常为有蒂，偶尔呈管状绒毛状或绒毛状。文中阐述了较大的化生息肉与大肠腺瘤之间的结构相似性，并强调了在鉴别这些病变时区分化生上皮与发育异常上皮的重要性。还描述了化生息肉的其他异常特征。有证据表明，男性比女性更易发生化生息肉。在幼年息肉中，男性腺瘤的发生率较低，但相对常见（20.8%）。最后，描述了7例患有多发性大肠化生息肉的患者，他们在治疗的某个阶段被诊断为腺瘤性息肉病。7例患者中有6例为男性，就诊时的平均年龄为37.4岁。在这些病例中，较大的化生息肉很常见。强调了在所有肠息肉病例中进行组织学确诊的必要性，并讨论了“化生息肉病”作为一种病理实体的可能性。
