Davis J K, Maddox P A, Thorp R B, Cassell G H
Infect Immun. 1980 Jan;27(1):255-9. doi: 10.1128/iai.27.1.255-259.1980.
Immunofluorescence was used to determine the relative percentages of T and B lymphocytes found in the lungs of normal and Mycoplasma pulmonis-infected F344 rats. Lymphocytes recovered from controls were approximately 25% T, 25% B, and 50% unclassified mononuclear cells. Infected animals had a 2.6-fold greater number of T cells and IgA-bearing cells, and a 1.6-fold greater number of unclassified mononuclear cells. These studies show that M. pulmonis infection significantly alters lung lymphocyte populations both quantitatively and in subpopulation distribution. Therefore, future studies of rat lung lymphocytes should utilize animals known to be free of this ubiquitous respiratory pathogen.
采用免疫荧光法测定正常和感染肺炎支原体的F344大鼠肺组织中T淋巴细胞和B淋巴细胞的相对百分比。从对照组回收的淋巴细胞中，T细胞约占25%，B细胞约占25%，未分类的单核细胞约占50%。感染动物的T细胞和含IgA细胞数量增加了2.6倍，未分类的单核细胞数量增加了1.6倍。这些研究表明，肺炎支原体感染显著改变了肺淋巴细胞群体的数量和亚群分布。因此，未来对大鼠肺淋巴细胞的研究应使用已知无这种常见呼吸道病原体的动物。
