Lying-Tunell U
Acta Radiol Diagn (Stockh). 1978;19(6):905-17. doi: 10.1177/028418517801900605.
By quantitative cisternography using a stationary detector system with correction for tissue background, an exponential elimination of 131I-HSA from the basal cisterns was demonstrated, allowing calculation of a biologic half time (BHT) of the clearance curve of a satisfactory level of reproducibility. 'Normal' range of BHT was calculated. Demented patients had significantly longer BHT. In 4 patients with normal pressure hydrocephalus prolonged BHT turned normal after shunting, paralleled by marked clinical improvement, in contrast to previous findings in 4 patients with presenile dementia. The method is now being modified employing 111In-DTPA and a computer assisted gamma camera for regional dynamic analysis.
通过使用带有组织本底校正的固定探测器系统进行定量脑池造影，证实了基底脑池内131I - 人血清白蛋白呈指数性清除，从而能够计算出具有满意再现性水平的清除曲线的生物半衰期（BHT）。计算出了BHT的“正常”范围。痴呆患者的BHT明显更长。4例正常压力脑积水患者在分流后延长的BHT恢复正常，同时临床症状显著改善，这与之前4例早老性痴呆患者的研究结果形成对比。目前正在对该方法进行改进，采用111In - 二乙三胺五乙酸（DTPA）和计算机辅助γ相机进行区域动态分析。
