Uchida K, Nomura Y, Takeuchi N
J Biochem. 1980 Jan;87(1):187-94. doi: 10.1093/oxfordjournals.jbchem.a132724.
Effects of sodium cholate, deoxycholate, chenodeoxycholate, and lithocholate on serum and liver cholesterol levels, bile flow, biliary cholesterol, phospholipids, and bile acids, and fecal sterols and bile acids were examined in Wistar strain male rats fed either an ordinary diet or a 2% cholesterol diet. Cholate and deoxycholate increased serum and liver cholesterol levels, serum pre beta-lipoprotein, bile flow, and biliary secretion of cholesterol, phospholipids, and bile acids, but chenodeoxycholate and lithocholate did not. The total amounts of sterols and of bile acids in the feces did not differ between the cholate and the chenodeoxycholate groups. All the bile acids except lithocholate decreased fecal coprostanol when the diet included cholesterol. Cholate and deoxycholate produced similar bile acid compositions in the bile and feces, as was the case between chenodeoxycholate and lithocholate, though chenodeoxycholate slightly increased the amount of muricholic acids, and lithocholate that of hyodeoxycholic acid, in the feces. The effects of cholate and deoxycholate are similar to each other but different from that of chenodeoxycholate or lithocholate in rats. Cholate causes marked accumulation of cholesterol in tissues, increased bile flow and biliary lipid secretion but chenodeoxycholate does not. Cholate is absorbed much more efficiently than chenodeoxycholate.
在喂食普通饮食或2%胆固醇饮食的Wistar品系雄性大鼠中，研究了胆酸钠、脱氧胆酸钠、鹅去氧胆酸和石胆酸对血清和肝脏胆固醇水平、胆汁流量、胆汁胆固醇、磷脂、胆汁酸以及粪便固醇和胆汁酸的影响。胆酸盐和脱氧胆酸盐可提高血清和肝脏胆固醇水平、血清前β-脂蛋白、胆汁流量以及胆固醇、磷脂和胆汁酸的胆汁分泌，但鹅去氧胆酸和石胆酸则无此作用。胆酸盐组和鹅去氧胆酸盐组粪便中固醇和胆汁酸的总量没有差异。当饮食中含有胆固醇时，除石胆酸外的所有胆汁酸均可降低粪便粪甾烷醇。胆酸盐和脱氧胆酸盐在胆汁和粪便中产生相似的胆汁酸组成，鹅去氧胆酸盐和石胆酸之间也是如此，不过鹅去氧胆酸盐会使粪便中鼠胆酸的量略有增加，而石胆酸会使猪去氧胆酸的量增加。在大鼠中，胆酸盐和脱氧胆酸盐的作用彼此相似，但与鹅去氧胆酸盐或石胆酸的作用不同。胆酸盐会导致组织中胆固醇的显著积累，增加胆汁流量和胆汁脂质分泌，但鹅去氧胆酸盐则不会。胆酸盐的吸收效率比鹅去氧胆酸盐高得多。
