Schick T D, Dersham G H, Jones S A, Han J
J Electrocardiol. 1980;13(1):37-44. doi: 10.1016/s0022-0736(80)80007-0.
Epicardial electrograms were recorded before and after occlusion of the left anterior descending coronary artery. The greatest difference between the post-occlusion and pre-occlusion depolarization times were determined. These times were referred to as the normalized times of greatest disparity, delta tmax. It was found that following both one- and two-stage occlusion of the LAD there was a significant increase in delta tmax in the ischemic area of the myocardium. This indicates increased asynchrony of depolarization. However, no significant change in depolarization times occurred in the unaffected area. In one-stage occlusion with an increase in delta t max there was a linear correlation with the development of ventricular arrhythmias, especially ventricular premature beats and tachycardia. Thus, there is evidence which links the increase in depolarization times with the mechanism of reentry and ventricular arrhythmias.
在左前降支冠状动脉闭塞前后记录心外膜电图。确定闭塞后与闭塞前去极化时间的最大差异。这些时间被称为最大差异标准化时间，即δtmax。结果发现，在LAD进行一期和二期闭塞后，心肌缺血区域的δtmax均显著增加。这表明去极化的不同步性增加。然而，未受影响区域的去极化时间没有显著变化。在一期闭塞中，随着δtmax的增加，与室性心律失常尤其是室性早搏和心动过速的发生呈线性相关。因此，有证据表明去极化时间的增加与折返机制和室性心律失常有关。
